Infection with Toxoplasma gondii is acquired by direct contact with food through ingestion of undercooked or raw meat containing the parasite cysts, congenitally through the placenta , or from oocyst contamination of soil or water. In natural oral infections, histopathological studies demonstrate parasite invasion of a variety of cell types in the gut and subsequently disseminating throughout the body . After crossing the intestinal epithelium, T. gondii spreads into several tissues and traverses biological barriers to reach immunologically privileged sites such as the brain and eyes where it can cause severe pathologies<br />Typical main clinical features: Lymphadenopathy +- chorioretinitis. <br />Diagnosis: Clinical + investigations. <br />Investigations: Serology. <br />Management: Sulphonamide + pyrimethamine.