The use of antimicrobials is the key to prevention of many life threating causing microorganisms.<br />Antibiotics can be beneficial for treating minor and serious bacterial infections targeting specific bacterium in order to reduce or inhibit their growth. Antibiotics have a wide range of applications including skin infections due to skin lesions, food poisoning, pneumonia and even fatal infectious diseases such as tuberculosis and meningitis. Moreover, the use of antibiotic medications following any surgical procedure helps to prevent wound infections in patients who are susceptible to infections when the immune system is compromised. Over the years, enhancements of science and technology has been increasingly improving as well as the medical technology. Such enhancements encouraged the distribution and use of antibiotics worldwide extensively. <br />The development of antimicrobial resistance has become one of the major challenges in medicine impacting the global health overall. This is when a microorganism starts to evolve in a way that will hinder the function of antibiotics designed specifically to target specific bacterial cells reducing the overall efficacy of antibiotics hence it become a life-threating to individuals if not treated. Reducing antibiotic resistance is vital and has become a priority for the World Health Organization (WHO), pharmaceutical industry, and many other national health agendas.<br />Misuse of antibiotics also a major worldwide issue endangering many lives and has been reported to be the result of antibiotic misuse or overuse. The overuse of antibiotics or failure to follow the instructions as prescribed by clinicians lead to the increase of bacterial organisms’ resistance against antibiotics.<br /> There is a strong evidence indicating that antibiotic use in human medicine does not only vary from one person to another, but it also relates to the geographical location associated with different health systems, primary health care structural components, medical education as well as the cultural and socioeconomic determinants. <br />There is increasing evidence showing that antibiotic use in human medicine does not only vary according to patient characteristics (medical determinants) but also according to geographical location associated with different health systems, reimbursement systems, medical education, primary care structural components, socioeconomic and cultural determinants.<br />