The use of Big Data represents one of the most important modern transformations in the medical field, enabling a shift from generalized treatments to personalized therapies that take into account the individual characteristics of each patient. Big Data in healthcare relies on the collection of vast amounts of information, including electronic health records, laboratory test results, medical imaging, genomic data, and lifestyle-related information. This extensive data foundation allows for advanced analytical methods that support informed medical decision-making. Analyzing Big Data contributes significantly to the personalization of medical treatments by revealing patterns and hidden relationships within complex health data that cannot be easily identified through traditional approaches. By examining a patient’s medical history and previous responses to medications, clinicians can better predict treatment effectiveness and reduce the likelihood of adverse side effects. Furthermore, Big Data analysis enables early identification of potential health risks, allowing for timely preventive or therapeutic interventions tailored to the individual patient. Artificial intelligence applications play a crucial role in improving treatment outcomes based on personal data. Machine learning and deep learning algorithms process and analyze large-scale health data with high accuracy, enabling intelligent therapeutic recommendations such as selecting the most appropriate medication and determining optimal dosages for each patient. These AI-driven systems also monitor patient progress and continuously update treatment plans according to the individual’s response to therapy. In addition, the integration of Big Data and artificial intelligence enhances the overall quality of healthcare by supporting predictive medicine, advancing personalized care, reducing medical errors, and improving the efficiency of healthcare resources. With the rapid advancement of data analytics technologies, personalized treatment based on Big Data is expected to become a fundamental component of the future of medicine, offering more precise, effective, and patient-centered healthcare solutions. Al-Mustaqbal University is the first one university in Iraq.