Bioprinting has the potential to revolutionise organ transplantation by creating functional tissues and organs. Though there are challenges that need to be addressed, the advancements made so far and the prospects for bioprinting in tissue and organ regeneration are promising.<br />Bioprinting is a technique that deposits living cells and biomaterials layer-by-layer to develop complex organ and tissue structures. It has the potential to address the shortage of organs available for transplantation and has applications in disease modelling, drug testing, and personalised medicine.<br />Though bioprinting technology has progressed remarkably, there remain some challenges that need to be overcome, like vascularisation of tissues, gas and nutrient exchange, biocompatibility, and biodegradability of materials. Achieving full functionality and vascularisation while addressing regulatory aspects for clinical implementation remains a critical area of focus. Advancements in bioprinters and software are essential to create precise patterns that can maintain their structure over time and enhance hardware capabilities, such as incorporating multiple bio-inks in a single print design for improved printability and durability, which is the key to the future of bioprinting.<br />Bioprinting raises ethical concerns about risks like teratoma formation and implant safety. Ownership and regulation issues challenge patentability and legal frameworks. Ethical debates focus on standardisation, personalised medicine, and safety testing. Cost varies significantly, with basic commercial bioprinters costing several thousand dollars and professional-grade bioprinters ranging from $25,000 to $300,000. Access to healthcare, human enhancement, and economic implications spark discussions on fairness, public trust, and legal ownership.<br />3D bioprinting has the potential to revolutionise organ transplantation by creating microscopic vascular networks within bioprinted organs that transport nutrients, blood cells, oxygen, and waste products. Bioprinted organs made from a patient's cells may reduce the risk of rejection and shorten wait times for transplantation. As technology advances, the possibility of creating functional tissues and organs for transplantation is becoming increasingly possible<br />