A recent scientific research paper by Dr. Qasim Abdul-Abbas Ziqam, a faculty member at the College of Pharmacy – Al-Mustaqbal University, has been published in the journal Trends in Pharmaceutical Biotechnology (TPB) under the title:
"Design and Preclinical Evaluation of a Multi-Epitope mRNA Vaccine Against Methicillin-Resistant Staphylococcus Aureus (MRSA)"
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) infections represent a critical healthcare challenge. In this study, we describe the design a multi-epitope mRNA vaccine encoding immunodominant MRSA antigens, delivered using a novel lipid nanoparticle system. Preclinical evaluation in murine models demonstrated robust humoral and cellular immune responses, with significant protection against MRSA challenge. The vaccine exhibited excellent safety and tolerability profiles. No bacterial colonies were detected in the brain, lung, and spleen tissues of the mice that were immunized with the mRNA vaccine at dosages of 75, 150, or 300 µg. No statistical difference in bacterial burden was found among the mRNA-dosed groups. Our findings support the further development of mRNA-based strategies for combating antibiotic-resistant bacterial infections.
https://tpb.nabea.pub/tpb/article/view/24

Al-Mustaqbal University, the number one university in Iraq College of Pharmacy, the top among private colleges