Systemic Lupus Erythematosus (SLE), commonly known as lupus, is a chronic autoimmune disease in which the immune system attacks the body’s own tissues and organs instead of protecting them. This leads to inflammation and damage in various systems such as the joints, skin, kidneys, brain, heart, and lungs. It is considered one of the most mysterious and complex diseases due to its wide range of symptoms that vary significantly from person to person. The disease can appear suddenly or develop gradually, and it affects women more frequently than men, especially during childbearing years. The exact cause of lupus remains unknown, but research suggests a combination of factors including genetics, environmental triggers such as sunlight or viral infections, and hormonal influences, particularly the hormone estrogen. Symptoms of lupus include a characteristic butterfly-shaped rash across the cheeks and nose, joint pain and stiffness, chronic fatigue, unexplained fever, hair loss, photosensitivity, mouth ulcers, and involvement of internal organs such as the kidneys, nervous system, or heart. Psychological symptoms such as depression, anxiety, or memory issues may also occur. There is no single definitive test for lupus; diagnosis relies on a combination of blood tests such as ANA and Anti-dsDNA antibodies, urine analysis, clinical examination, and in some cases, tissue biopsies. Treatment focuses on controlling symptoms and preventing complications rather than curing the disease. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve joint pain, corticosteroids reduce inflammation, and immunosuppressive medications like azathioprine and methotrexate help suppress abnormal immune responses. Hydroxychloroquine is often used for skin and joint symptoms. It is essential for patients to adopt a healthy lifestyle including balanced nutrition, adequate rest, stress reduction, and avoiding direct sun exposure, along with regular follow-up with healthcare providers. Living with lupus requires patience and understanding, as the disease fluctuates between periods of flare-ups and remission. Therefore, patients must be well-informed about their condition and receive the necessary psychological and social support. Although lupus is a chronic disease, medical advancements have significantly improved patients’ quality of life, enabling them to adapt and manage the disease effectively, especially when diagnosed early and treated properly.