Ehlers–Danlos syndrome (EDS) is a group of inherited connective tissue disorders caused by defects in collagen synthesis or structure. Collagen is essential for the strength and elasticity of skin, joints, blood vessels, and other tissues. As a result, patients with EDS have fragile and overly flexible connective tissues. Key clinical features include: • Joint hypermobility with frequent dislocations • Hyperextensible and fragile skin • Easy bruising • Poor or delayed wound healing • Chronic musculoskeletal pain • In some subtypes, especially the vascular type, there is an increased risk of arterial rupture or aortic aneurysm The severity and complications of EDS vary depending on the subtype, ranging from mild joint symptoms to life-threatening vascular involvement. • Malfait F, Francomano C, Byers PH, et al. The 2017 International Classification of the Ehlers–Danlos Syndromes. American Journal of Medical Genetics Part C (Seminars in Medical Genetics). Mustaqbal University The first university in Iraq