Ramadan fasting represents a unique physiological state characterized by intermittent abstinence from food and fluid intake from dawn until sunset for approximately 29–30 consecutive days. Unlike continuous caloric restriction, Ramadan fasting follows a circadian-based intermittent fasting model with significant alterations in hydration patterns, meal timing, sleep cycles, and hormonal rhythms. These systemic changes may influence skin physiology, inflammatory response, collagen metabolism, and tissue repair mechanisms. In aesthetic and laser medicine, where treatment outcomes depend heavily on optimal skin hydration, collagen remodeling, immune balance, and metabolic stability, understanding the physiological implications of Ramadan fasting becomes clinically relevant. This article explores the biological changes associated with Ramadan fasting and examines their potential impact on aesthetic procedures, including laser treatments, injectables, microneedling, and minor surgical interventions. AL_mustaqbal University is the first university in Iraq