بحوث سكوبس — سامر عزت مالك حسين

Psoriasis is a life-long immune-mediated dermatosis with thickened, reddish, and flaky skin patches. Canagliflozin is a gliflozin antidiabetic with non-classical remarkable antioxidative, anti-inflammatory, anti-proliferative, and immune-modulating effects. The aim of this study is to examine the probable effects of topical canagliflozin on a mouse model of imiquimod-provoked psoriasis-like dermatitis. The study evaluated 20 Swiss white mice, sorted haphazardly into 4 groups of 5 animals each. Every mouse, with the exception of the control group, had imiquimod applied topically to their shaved backs for 7 days. The control group included healthy mice that were not given any treatment. Mice in the other three groups underwent topical treatment with vehicle (induction group), 0.05% clobetasol propionate ointment (clobetasol group), or 4% canagliflozin emulgel (canagliflozin 4% group) on exactly the same day as imiquimod cream was administered. Topical canagliflozin markedly lowered the intensity of imiquimod-provoked psoriasis eruptions, featuring redness, glossy-white scales, and acanthosis, while also correcting histopathological aberrations. Canagliflozin administration to imiquimod-exposed animals resulted in significantly decreased cutaneous concentrations of inflammatory mediators such as IL-8, IL-17, IL-23, and TNF-α, with raised levels of IL-10. Canagliflozin further lowered proliferative factors involving Ki-67 and PCNA, diminished oxidative indicators such as MDA and MPO, and augmented the activity of antioxidant markers, notably SOD and CAT. Canagliflozin might alleviate the imiquimod-induced animal model of psoriasis, probably thanks to its profound anti-inflammatory, antioxidant, antiangiogenic, and antiproliferative activities. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

In our study, zinc oxide (ZnO) nanoparticles (NPs) were prepared by precipitation (economically and in high quality) at a temperature range of 60°C to 80°C and at pH 8, and were then adorned with graphene (G) plates. To determine its antimicrobial potential, the ZnO/G complex was loaded with metronidazole. The morphology and diameter of the ZnO nanocomposite before and after the loading were validated by scanning electron microscopy. The average size of the ZnO NPs was found to be 20–40 nm, while X-ray diffraction examined how the physical features of these NPs varied from those of its individual components with an average size of 28.1 nm. The assessment of the ZnO/G complex’s antibacterial efficacy against Gram-positive and Gram-negative bacteria was the main aim of our work. The agar well diffusion technique was used in order to assess the antibacterial activity of the ZnO/G complex with and without metronidazole. Our study demonstrates that the ZnO/G complex possesses antibacterial activity and might increase the antibiotic action by inhibiting Gram-positive bacteria (more than Gram-negative ones). It is, therefore, concluded that the ZnO/G NPs could be of use in formulating nano-drug conjugates that could act as antimicrobial agents. © 2024 by the authors.

Background: Students’ lifestyles and eating habits can be disturbed due to their busy work schedule. Objectives: This study is aimed to assess the prevalence of healthy habits among students from the private colleges of pharmacy and Physical Education Sport Sciences in Iraq. Materials and Methods: A total of 358 students of Al-Mustaqbal University in Babylon province, Iraq were participated in this cross-sectional study. Face-to-face interviews were conducted using a predesigned questionnaire, which includes questions on the student’s sociodemographic information, weight status, meal habits, smoking status, alcohol use, fried food consumption, and overall fruits and vegetables intake. The Statistical Program for the Social Sciences (SPSS) software was used to determine descriptive statistics. Results: Students’ body mass index (BMI) revealed that 2.9% of male students were underweight, 51.2% were normal, and 37.3% were overweight, whereas 6.4% of female students were underweight, 64% were normal, and 26.4% were overweight. Eating irregularly was highly reported between females and males (P < 0.001). More students in sports science eat breakfast daily compared with students in pharmacy. Of the total sample, 37.1% and 44.4% of students reported regularly snacking and consuming fried food, respectively. Female student smoking was reported (P < 0.001). Students reported rarely drinking alcohol. Conclusions: The findings of this study indicated that students attending private college had lifestyle behaviors that range from healthy to unhealthy. These behaviors were potentially affected by gender and college type. © 2024 Medical Journal of Babylon | Published by Wolters Kluwer - Medknow.

Because nanomaterials are highly reactive and electronically sensitive towards a variety of drug molecules, they are thought of as efficient drug sensors. In the present research study, an aluminum carbide (C3Al) monolayer is employed and its interaction is examined with cyclophosphamide (CP) by performing DFT computations. The C3Al monolayer is highly reactive and sensitive towards CP according to the computations. CP interacts with the C3Al monolayer with the adsorption energy of −31.39 kcal/mol. A considerable charge transfer (CT) indicates an enhancement in the conductivity. Also, the charge density is explained based on the electron density differences (EDD). The decrease in CP/C3Al energy gap (Eg) by approximately 52.91% is due to the remarkable effect of adsorption on the LUMO and the HOMO levels. Therefore, due to the decrease in Eg which can generate an electrical signal, the electrical conductivity is considerably increased. These results suggest that the C3Al monolayer can be employed as a proper electronic drug sensor for CP. Also, the recovery time for the desorption process of CP form the surface of C3Al is 351 s at 598 K. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

This study aimed to synthesize new ferulic acid derivatives through preparing new compounds containing a heterocyclic group that are expected to be biologically effective for diagnosis and studying pharmacological efficacy through these groups. These new compounds are primarily screened (in vitro) for their cytotoxic activity against human lung (A549) and breast (MCF-7) cancer cell line, 1H-NMR, 13C-NMR spectroscopy, and FT-IR spectra. Pharm kinetic study by Swiss ADME suite was examined, utilizing molecular docking software (GOLD suite v. 5.7.1), the selectivity for EGFR and ER-receptors, cytotoxicity evaluation tested compounds in vitro IC50 showed compounds (4a and 4b) are more active anticancer (478.32 and 561.12 µg/mL), respectively than reference erlotinib (582.73), while the compounds 4a, 4b, and 4c, respectively is the more active anticancer than standard tamoxifen (392.3 µg/mL). © 2023 by SPC (Sami Publishing Company)