بحوث سكوبس — ذوالفقار علي عبد حصيني

In this study, we loaded Ag with CuO NPs that had previously been synthesized using the chemical reduction technique to develop antimicrobial performance for Ag-CuO nanocomposite materials. The structure analysis, morphology, and chemical properties of Ag, CuO and Ag-CuO NPs were analyzed via Scanning Electron Microscopy analysis (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Energy Dispersive X-ray (EDX). XRD patterns proved cubic and monoclinic phases for Ag and CuO, respectively. antibacterial activity of CuO, Ag and Ag/CuO was investigated by agar diffusion method on clinically isolated bacteria of Staphylococcus aureus and E.coli, the results indicated antibacterial effect of Ag/CuO followed by Ag then by CuO, moreover, effect of these chemicals on Gram negative bacteria (E.coli) was larger than on Gram positive bacteria (S. aureus). © 2025 The Author(s). Published by Oxford University Press.

In this study, alpha iron oxide (αFe2 O3) nanoparticles (NPs) were successfully synthesized via a simple, cost-effective thermal precipitation method, with reaction parameters (such as temperature and alkalinity) systematically controlled in order to ensure high-quality outcomes. The structural and morphological properties of αFe2 O3 NPs were characterized using Fourier-transform infrared spectros-copy (FT-IR), scanning electron microscopy (SEM), and X-ray dif-fraction (XRD). XRD analysis confirmed a hematite phase with an average crystallite size of 24 nm, while SEM imaging revealed NPs of defined morphology with an average particle size of approximately 57 nm. The antibacterial activity of αFe2 O3 NPs against the Gram-pos-itive bacterium Staphylococcus aureus was assessed using the agar well diffusion method. The NPs were tested at concentrations of 10, 15, 20, and 25 mg/mL, and their efficacy was compared to that of a standard antibiotic. The results demonstrated notable antibacterial activity at concentrations of 15 mg/mL and above, with clear zones of inhibition observed against S. aureus. © 2025, ZITA Medical Management. All rights reserved.

A series of Naproxen-based heterocyclic derivatives (NA1-NA4) were designed, synthesized, and evaluated for their antibacterial and anticancer activities. These heterocyclic derivatives were developed by integrating Naproxen with various heterocycles, including indole, benzothiophene, benzothiazole, and pyrazole, in order to enhance efficacy while reducing gastrointestinal side effects. The synthesized compounds were characterized using FT-IR, 1H NMR, and 13C NMR spectroscopy. The antibacterial activity was evaluated against S. aureus (Gram-positive) and two Gram-negative bacteria (P. aeruginosa and K. pneumonia) by measuring the diameter of the zone of inhibition. Compounds NA2 and NA3 showed promising inhibitory activity against the tested bacteria compared to amoxicillin. The anticancer activity of NA1-NA4 compounds against the MDA-MB-231 human breast cancer cell line was assessed by determining the IC50 values (the concentration required to inhibit 50 % of cell viability). NA1 and NA3 exhibited notable antiproliferative effects with IC50 values of 11.81 and 11.08 μg/mL, respectively. Molecular docking studies of compounds NA1-NA4 were performed against COX-2 enzyme (PDB Code: 3NT1) using MOE software. The compounds showed strong binding affinities, indicating potential anti-inflammatory properties. Collectively, the antibacterial, anticancer, and molecular docking data suggest that these Naproxen derivatives possess promising multifunctional therapeutic potential. © 2025 The Authors.