بحوث سكوبس — امام عطية

Abstract: One of the most extensively distributed elements in the Earth’s crust is aluminum sulfate Al2(SO4)3, used in vaccinations, medications, and food additives. Vitamin C, a necessary nutrient, cannot be generated by humans due to the absence of a crucial enzyme in the biosynthesis route. Previous studies do not report enough data on the role of aluminum sulfate Al2(SO4)3 and vitamin C as companions, so the current study addressed this affair. The twenty rats were divided into 4 groups, five for each group: group 1―control, group 2―accompanied by Al2(SO4)3 at 0.1 mg/1, group 3―accompanied by Al2(SO4)3 at 0.2mg/L and group 4―Al2(SO4)3 at 0.2 mg/L plus vitamin C. For 21 days, the appropriate doses were given orally to rats. Histological analysis of the heart tissue revealed that a lack of effect of aluminum sulfate on inflammatory cells especially macrophages, meaning that vitamin C had an antagonistic effect on aluminum sulfate in when treated doses of Al (0.2 mg/L) with vitamin C. © Pleiades Publishing, Ltd. 2025.

To assess the biological potential of an Er complex that contains a 2,2'-bipyridine ligand, various techniques such as multispectral and molecular modeling procedures were utilized to examine its DNA-binding ability, BSA binding affinity, antimicrobial effects, and anticancer properties. By analyzing fluorescent information and employing the vant’ Hoff equation, important parameters such as the innate docking coefficient (Kb), Stern-Volmer coefficient (KSV), and thermodynamic properties including modifications in liberated energy (ΔG°), enthalpy (∆H°), and entropy (∆S°) were determined. The trial findings suggest that the compound can bind to DNA, primarily through groove binding. Additionally, the engagement between the Er compound and the protein BSA was examined using emission spectroscopy technique, revealing a powerful binding affinity between the compound and BSA. The Er complex binds to BSA primarily via hydrogen links and van der Waals forces, as indicated by the adverse values of ΔH° and ∆S°. Through a static quenching process, the complex significantly reduces the intrinsic fluorescence of BSA. Molecular binding calculations and rivalrous binding trials confirm that this compound dock to hydrophobic remains found in site III of BSA. Additionally, the Er complex demonstrates promising results in terms of its anticancer and antimicrobial activities based on screening tests. Copyright © 2023 Thanoon, Ibadi, Ahmad, Alamir, Alwan, Hashim, Khaled, Alkhafaji, Asiri and Alsaalamy.

Polyethylene glycol (PEG) was used for a wide range of medical and biological applications. The health problems that PEG can cause is the conversion of alcohol dehydrogenase by metabolic oxidation into oxalate. Moringa oleifera contains about 46 antioxidant compounds such as β-carotene and various phenolics. Previous studies did not report enough data on the hepatotoxicity of polyethylene glycol and the protective role of Moringa oleifera. Therefore, the current study was conducted to address this affair. Male rats were split for six set (six each group): control group 1, MOLE (200 mg/ kg) group 2, PEG (50 mg/kg) group 3, MOLE plus PEG (50 mg/kg) group 4, PEG (100 mg/kg) group 5, and MOLE plus PEG (100 mg/kg) group 6. Rats administered orally daily for 45 days. The obtained results showed that treatment with both doses of PEG caused significant increase in DNA breakages, TNF-α, IL-6, TBARS, and NOx comparison to group 1. While, both doses of PEG caused significant suppressed expression of PGC-1α and mtTFA, the P53 level, catalase, GR, and GSH were decline, as compared with group 1. It was concluded that the co-supplementation with MOLE caused significant hepatoprotection against PEG-induced liver toxicity at all levels. © 2023 by SPC (Sami Publishing Company)

Metal and metal oxide NPs have shown to be perfectly synthesized by using plant extracts with high efficiency, low cost and low toxicity. Our goal was to synthesize ZnO NPs by using an extract of pomegranate seeds and investigate the anticorrosion, antimicrobial and antioxidant properties of the synthesized ZnO NPs. The results have shown that the use of pomegranate in the green synthesis of ZnO NPs gave a good yield, with a low cost and non-toxic approach. The electrophoretic deposition (EPD) was used to coat stainless steel (S.S) by synthesized ZnO NPs in an alcoholic solution at room temperature producing a good coating against corrosion. The corrosion properties were investigated in a saline solution and a temperature range of (293–323) K. The effect of ZnO NPs against the growth of two Gram-negative bacteria Escherichia coli and Klebsiella sp., as well as the two Gram-positive bacterial strains Staphylococcus epidermidis and Staphylococcus aureus, as well as Candida albicans was at a very good scale. ZnO NPs have shown good properties as antioxidants to scavenge DPPH radicals. These therapeutic properties of ZnO NPs make them valuable in the medical field. © 2022, Russian Association of Corrosion Engineers. All rights reserved.

Polyethylene glycols (PEG) are water-soluble chemicals composed of periodic ethylene glycol units, mostly used in industry and medicine. They have several chemical and physical features, which may lead to possible toxicity. Moringa oleifera is used as an antioxidant because of its ability to inhibition of protein denaturation and scavenge free radicals. Previous studies do not report enough data on the nephrotoxicity of polyethylene glycol and the protective role of Moringa oleifera leaf extract (MOLE). So, the current study was conducted to address this affair. Male rats were split for six set (six each group) (group 1, as control; group 2, MOLE; group 3, PEG 50 mg/kg; group 4, MOLE + PEG 50 mg/kg; group 5, PEG 100 mg/kg; group 6, MOLE + PEG 100 mg/kg). Rats were administered orally daily for 45 days. The obtained results showed that treatment with both doses of PEG caused a significant increase in IL-6, TNF-α, NOx, TBARS, uric acid, and GST comparison to group 1. While, both doses of PEG significantly suppressed expression of PGC-1α, levels of p53, GR, GPx and GSH declined compared to group 1. The co-complementary with MOLE leads to safeguarding the kidney from the toxicity induced by PEG at all levels. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

Petroleum hydrocarbons are one of the most prevalent and ubiquitous environmental pollutants, causing health and environmental risks, so some isolates from cows and buffalos were used in this study to remove these pollutants. Nine isolates of Lactobacillus spp from 20 samples of cows and buffalos milk types. 5 Lactobacillus acidophilus isolates were used in this study because of their excellent production of bacteriocin compared with the other species. The isolates were purified as follows: 70% saturation of ammonium salt followed by gel filtration on Sephadex -G150 was used to purify the bacteriocin. It resulted in a 47.75 % yield with 4.7-fold purification. The results of this study showed the use of 80μg/ml of bacteriocin increased the removal of hydrophobic pollutants from the burned motor and engine oils by 41% after 24 hours, which was more efficient than high doses of bacteriocin. For example, 100 μg/mL of bacteriocin removed only 33% of the contaminants. Furthermore, by extending the incubation period to 7 days, the hydrocarbon degradation percentage was increased by 78% in engine oil and 89% in burned motor oil. Thus, it can be concluded that bacteriocin bioremediation is an efficient and cost-effective biological treatment for eliminating petroleum hydrocarbons from water and protecting natural resources. © Published under licence by IOP Publishing Ltd.