بحوث سكوبس — وداد عبدالجبار موزان الساعدي

Background: Up to ninety percent of pregnant mothers experience nausea and vomiting in pregnancy (NVP) which is the most prevalent medical condition during pregnancy. Hyperemesis gravidarum (HG), a severe prognosis form of nausea and vomiting, affects 0.3% to 3.6% of pregnant mothers in the world. HG is lead to fetal and maternal morbidity as well as nutritional deficiencies during pregnancy period in addition to its effect on mentality, injury to oesophagous, and birth abnormalities such as premature delivery, low birth weight. The purpose of the present research is to assessing the safety of doxylamine & pyridoxine combination in nausea and vomiting in pregnancy compared to B6 only. Patients and methods: One hundred fifty pregnant women suffering from nausea and vomiting during pregnancy were enrolled in this study. Randomized divided into two groups, group 1 (n= 75) receive (doxylamine and B6) and group 2 (n= 75) receive B6 only for 15 days with a dosages varying from 2–4 tablets \ day, Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) score were assessed at 0 time and at three, six, fifteen day of study, blood samples were collected at 0, and 15 day of study for determination of Ferritin & potassium level. Results: Doxylamine 10 mg and pyridoxine 10mg (B6) use has a good effect in controlling N&V in pregnancy over B6 only. Conclusions: Doxylamine–pyridoxine together is well absorbed in pregnancy and very safe specially when taken as a prescribed dose of up to four tablets per day for treating nausea and vomiting during pregnancy. © 2024, Medical Project Poland. All rights reserved.

s: Reports indicate that renal injury or damage results in high mortality. Aim: To evaluate the beneficial aspects of hesperetin in treating kidney injury in male mice caused by ischemia-reperfusion (IR). Materials and Method: Twenty-eight male Swiss Albino mice with weight range of 35–38 g at 12–16 weeks old were gathered into 4 groups; each group had seven mice, as follows: group I (sham group) undergone all research surgical techniques, with the exception of the use of vascular clamps for occlusion and reperfusion on the pedicles. group II (IR group) was subjected to reperfusion and ischemia. group III (DMSO group), Hesperetin's solvent is (DMSO)dimethyl sulfoxide was subjected to intraperitoneal injection of 1.5 mg/kg of DMSO 30 min prior to the exposure to renal IR processes under anesthesia. group IV (hesperetin treated group) was subjected to intraperitoneal injection of 50 mg/kg of hesperetin 30 min before being subjected to IR procedures while sedated. Mice underwent euthanization, and then a blood sample from the heart was taken to measure the levels of urea, creainine, MDA, and glutathione peroxidase (GPx) in the serum. Bilateral nephroctomy was performed and the kidney sample underwent homogenization so that the tissue markers can be measured (IL1 and IL6). A part of the kidney sample was placed in paraffin blocks with a 10% formalin solution. and prepared for histological examination. Results: The results demonstrated that the average (mean) tissue levels of (IL1, IL6, and MDA), also the mean serum concentration of (urea and creatinine) and the histopathological changes scores compared to the sham group, increased significantly (P< 0.05) in the IR group, while the activity of glutathione peroxidase (P < 0.05) was reduced compared with other groups. In the hesperetin treated group, the mean levels of IL1, IL6, and MDA as well as the mean urea and creatinine levels in the blood underwent significant (P<0.05) reduction. Similarly, the histopathological changes scores were decreased, while the glutathione peroxidase (P < 0.05) activity was higher compare with other groups Hesperetin reduces kidney injury caused by ischemia and reperfusion through their pleiotropic effects by modulating the inflammation pathway and oxidative activity. © 2023 Nsoe et al.; Licensee Cosmos Scholars Publishing House.