بحوث سكوبس — عهد حميد جعاز اللامي

When nanotechnology is used in medicine, it makes it easier to find and treat a wide range of diseases. The potentially fatal disease multiple sclerosis (MS) has a disproportionately large impact on young people. One of the oral options for treating this condition is dimethyl fumarate (DMF). This study aimed to use platelet membranes and polymeric nanoparticles (PNs) to develop a drug delivery system that mimics biological cells to treat MS. Here, we produced and characterized solid lipid nanoparticles (SLNs) containing dimethyl fumarate (DMF). To make SLNs, DMF is combined with biocompatible lipids using hot emulsion and ultrasonication techniques. These DMF-SLNs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), FTIR spectroscopy, and a zeta meter instrument. Characterization revealed that the optimal SLNs had a polydispersity index of (0.28, 0.96, 0.77), a zeta potential of (-22.73 mV,-28.7 mV, and-30.13 mV), and a mean particle size of (562 nm, 1997 nm, and 849 nm). The results of this study suggest that the present formulation may be a potential longer-acting formulation for the improved management of MS. SLNs could significantly change the treatment of many illnesses by providing effective drug delivery. © 2025 by SPC (Sami Publishing Company).

In the realm of materials science and corrosion mitigation, the utilization of inhibitors has garnered substantial attention for safeguarding metal assets. This research delves into the proficient utilization of 4-phenyl-1-(phenylsulfonyl)-3-thiosemicarbazide (PP-3-T) as a corrosion inhibitor for mild steel in hydrochloric acid (HCl) solutions, as evaluated through weight loss measurements. The investigation reveals that the incorporation of PP-3-T into the HCl medium engenders a significant enhancement in the corrosion resistance of mild steel, attributed to the formation of a protective barrier via PP-3-T molecule adsorption. A notable finding of this study is the independence of the corrosion inhibition efficiency on variables such as PP-3-T concentration, immersion time, and temperature. The best inhibition efficiency of 96.1% for mild steel immersed in 1 M HCl solution is achieved in the presence of 0.5 mM PP-3-T. Furthermore, the inhibitory effect diminishes significantly as immersion time is extended from 10 to 48 hours at a constant PP-3-T concentration, highlighting the time-sensitive nature of the inhibition process. Alterations in temperature within the range of 303 to 333 K exhibit negligible impact on inhibition efficiency, indicating the robustness of the corrosion protection mechanism. The adsorption isotherm analysis accentuates the adherence of PP-3-T to the Langmuir adsorption model on mild steel, emphasizing the layer formation of the protective barrier. Insights from Density Functional Theory (DFT) quantum chemical calculations reveal critical molecular attributes of PP-3-T governing its corrosion inhibition potential. Parameters such as adsorption energy (ΔE), highest occupied molecular orbital energy (EHOMO), lowest unoccupied molecular orbital energy (ELUMO), energy gap (Egap), as well as chemical reactivity indices encompassing total hardness (η), electronegativity (χ), and electron density transfer (ΔN), elucidate the corrosion inhibition mechanism of PP-3-T. In essence, this comprehensive study unveils the corrosion inhibition efficiency of PP-3-T for mild steel in HCl environments and elucidates the molecular underpinnings that govern its anti-corrosive prowess. These findings contribute to the expanding knowledge base concerning corrosion protection strategies and offer potential avenues for designing novel and efficient corrosion inhibitors. © 2024, Russian Association of Corrosion Engineers. All rights reserved.

The corrosion inhibition potential of 2-piperazin-1-yl-1,3-benzothiazole (PYB) for mild steel in 1.0 M hydrochloric acid (HCl) was comprehensively investigated through weight loss measurements and quantum chemical calculations. The study delved into the influence of various corrosion inhibition parameters, including PYB concentration, immersion times, and temperature. Remarkably, the highest inhibition efficiency of PYB reached 90.7% at a concentration of 0.5 mM and a temperature of 303 K. Notably, inhibition efficiency demonstrated an upward trend with increasing concentration. Weight loss techniques affirmed that inhibition efficiency correspondingly increased with prolonged immersion times, as well as with elevated temperature. Furthermore, the observed higher inhibition performance with increasing temperature was corroborated by the calculated ΔG° values, suggesting that PYB actively participates in both physical and chemical adsorption processes on the mild steel surface. The adsorption phenomenon adhered to the Langmuir adsorption isotherm, as supported by experimental and theoretical findings, which exhibited commendable agreement. This study presents a comprehensive understanding of the corrosion inhibition mechanism of PYB, offering valuable insights for future applications in corrosion mitigation strategies. © 2024, Russian Association of Corrosion Engineers. All rights reserved.

When nanotechnology is used in medicine, it makes it easier to find and treat a wide range of diseases. One of the oral options for treating multiple sclerosis (MS) is dimethyl fumarate (DMF). DMF has been shown to be effective in lowering inflammatory diseases; nevertheless, it is characterized by several undesirable side effects that reduce patient compliance and add financial obstacles. The aim of this study was to use platelet membranes and platelet na-noparticles to generate a drug delivery system that works like a cell, so as to treat MS. During the experiments, there is a chance that the DMF solution might harden at room temperature. Therefore, in order to produce solid lipid nano-particles (SLNs), DMF was combined with biocompatible lipids. The creation of SLNs involved the use of hot emulsion and ultrasonication. These DMF-SLNs were characterized by means of scanning electron microscopy, and Fourier-transform infrared spectroscopy. The herein demonstrated enhanced qualities of the devised SLNs suggest that the formulation may be a potential, longer-acting formulation for the improved management of MS. SLNs could change the way many illnesses are treated in a big way, if they are used for the delivery of medicines. © 2024 by the authors.