بحوث سكوبس — هنادي هادي جاسم الخفاجي

Lawsone, a naturally occurring compound found in henna, has been used in traditional medicine for centuries due to its diverse biological activities. In recent years, its nanoparticle-based structure has gained attention in cancer and infectious disease research. This review explores the therapeutic potential of lawsone and its nanoparticles in the context of cancer and infectious diseases. Lawsone exhibits promising anticancer properties by inducing apoptosis and inhibiting cell proliferation, while its nanoparticle formulations enhance targeted delivery and efficacy. Moreover, lawsone demonstrates significant antimicrobial effects against various pathogens. The unique physicochemical properties of lawsone nanoparticles enable efficient cellular uptake and targeted delivery. Potential applications in combination therapy and personalized medicine open new avenues for cancer and infectious disease treatment. While clinical trials are needed to validate their safety and efficacy, lawsone-based nanoparticles offer hope in addressing unmet medical needs and revolutionizing therapeutic approaches. © 2024 Wiley-VHCA AG, Zurich, Switzerland.

Today, with the indiscriminate use of antibiotics, we face the resistance of some bacterial strains against some antibiotics. Therefore, it is essential to report and synthesize new compounds with antimicrobial properties. A novel copper/dipicolinic acid–metal–organic framework cross-linked oxidized pectin and chitosan (Cu/DPA-MOF/OP/CS) hydrogel polymer was synthesized under environmental conditions with the controllable process, which uses biodegradable polymer compounds such as pectin and chitosan in its structure. The efficient physicochemical features of the synthesized Cu/DPA-MOF/OP/CS hydrogel using SEM, FT-IR, TGA, BET, XRD, and EDS/mapping were identified and confirmed. The newly synthesized Cu/DPA-MOF/OP/CS hydrogel showed activity against Gram-positive and Gram-negative bacterial strains and fungal species, and significant antibacterial and antifungal properties were observed. In antibacterial activity, the MIC against Gram-positive species was in the range of 16–128 mg/mL, the MIC against Gram-negative species was in the range of 64–256 mg/mL, and the MIC against fungal species was in the range of 128–512 mg/mL. In antimicrobial evaluations, in addition to the MIC test, the MBC test, the MFC test, and the IZD test were performed, and the results were reported. The results were compared with commercial antibiotics in the market. Development of novel nanostructures based on hydrogel polymers with distinctive functionality can affect the performance of these nanostructures in different areas. Copyright © 2023 Jasim Al-Khafaji, Alsalamy, Abed Jawad, Ali Nasser, Dawood, Hasan, Ahmad, Gatea and Younis Albahadly.

Caries is the most prevalent and widespread chronic oral disease. Traditional caries filling materials, due to their lack of anti-caries capabilities, can readily develop secondary caries. Nanomaterials proposed as an effective approach for caries treatment can inhibit biofilm formation. It also can not only reduce demineralization but also promote remineralization. In recent years, nanotechnology in anti-caries materials, particularly nano-adhesive and nano-composite resin, has advanced rapidly. Because inorganic nanoparticles (NPs) interfere with bacterial metabolism and inhibit biofilm development, inorganic NPs have emerged as a new trend in dental applications. Metal and metal oxide NPs by releasing metal ions, oxidative stress induction, and non-oxidative mechanisms showed significant antimicrobial activity. For applying metal and metal oxide NPs as anti caries agents, silver, zinc, titanium, copper, and calcium ions have been shown significant attention. Moreover, fluoride functionalized inorganic NPs were also employed to improve their efficacy of them. The fluoride-functionalized NPs can promote remineralization, and inhibit demineralization by enhancing apatite formation. In this review, we have provided an overview and recent advances in the use of inorganic NPs as anti caries agents. Furthermore, their antimicrobial, remineralizing, and mechanical impacts on dental materials were discussed. © 2023 The Authors

Students in colleges of dentistry in Iraq can prescribe some medications during the fourth and fifth year of their undergraduate study of dentistry under the supervision of their seniors in the dental clinics. Numerous researches in many countries all over the world has identified the gaps in pharmacotherapeutic knowledge among dental students, but no such researche was made in Iraq. This study aimed to measure knowledge and awareness of the side effects and drug interactions of the drugs that are mostly prescribed the dental clinics by Iraqi dental students. A cross-sectional study was directed among 890 undergraduate Iraqi dental students using a structured closed-ended online questionnaire regarding their perception, attitude, knowledge, and awareness toward drug prescription. The online survey was done from March to April 2022. The online questionnaires were completed by 890 Iraqi dental students. This study revealed that dental students had made many mistakes during drug prescriptions due to a lack of pharmacological information, especially regarding analgesics and antibiotic prescriptions. Over and irrational prescription of antibiotics was also found. © 2023 by SPC (Sami Publishing Company)